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Imagine Everyday Moments With Symptom Relief

You and your doctor can work together to find a medicine that may help improve your symptoms for certain conditions. XELJANZ is a pill approved to treat adults when 1 or more medicines called tumor necrosis factor (TNF) blockers have been used and did not work well or cannot be tolerated. See conditions below:

XELJANZ is approved to treat children ages 2 and older when TNF blockers did not work well or could not be tolerated. See conditions below:

13+ Years in RA

XELJANZ has been prescribed for more than 13 years, since initial approval in 2012, for adults with moderate to severe rheumatoid arthritis.* XELJANZ was approved for use in adults with active psoriatic arthritis* in 2017, adults with moderate to severe ulcerative colitis* in 2018, and adults with active ankylosing spondylitis in 2021.

In 2020, XELJANZ was approved for use in patients ages 2 and older with active polyarticular course juvenile idiopathic arthritis.*

In 2025, XELJANZ was approved for expanded use in children ages 2 and older with active psoriatic arthritis.*

*Indication revised to use in patients who have not responded or cannot tolerate one or more TNF blockers.

https://main--xeljanzcomxeljanz--pfizer.hlx.page/global/fragments/first-approved Metadata
The everyday movements

Hand stretches—along with an RA treatment that works for you—may help your joints.* Watch the video and stretch your hands in style with this 80s rewind.

*Source: Strengthening and stretching with Rheumatoid Arthritis of the hand (SARAH) Study

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Getting Started With XELJANZ

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How XELJANZ Works

XELJANZ is a Janus kinase (JAK) inhibitor that helps regulate an overactive immune system. It helps disrupt JAK pathways from inside the cells, which are believed to play a role in inflammation.

Discover Support Resources

Take an active role in your treatment with tools and support resources—delivered directly to you. We’ll start by sending a Welcome Kit in the mail and will follow up with occasional emails containing timely information and lifestyle tips.

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XELJANZ (tofacitinib) resource support brochures